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KMID : 1149220200280040429
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Korean Journal of Oriental Medical Prescription
2020 Volume.28 No. 4 p.429 ~ p.441
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Review of Research for Herbal Medicine on Systemic Sclerosis
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Roh Jong-Seong
Kim Sang-Chan
Byun Sung-Hui
Yoon Mi-Chung
Shin Soon-Shik
Sohn Dong-Hyun
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Abstract
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Objectives : Systemic sclerosis(SSc) is an autoimmune disease characterized by fibrosis of the skin and internal organs and vasculopathy. The purpose of this study was to investigate the trend in the research on SSc using herbal medicine.
Methods : We searched for papers which had both systemic sclerosis and herbal medicine from Pubmed, KCI and NDSL. After searching papers, we classified according to the study design and analyzed selected studies.
Results : 18 studies were searched. The types and numbers of study were as follows: 11 were in vitro or in vivo studies using herbal medicine or active components, and 7 were clinical research including case reports.
1. Herbal medicines include the therapeutic effects of “tonifying qi(補氣)” or “active blood(活血)” improved systemic sclerosis in vivo and in vitro studies.
2. Active components isolated from Herbal Medicine such as Astragalus membranaceus(黃?), Zhizi(梔子), Salvia miltiorrhiza(丹蔘) have anti-fibrotic effects.
3. Clinical trials showed that herbal medicine can improve the symptom of systemic sclerosis including skin fibrosis, Raynaud’s phenomenon, pain and gastric dysmotility.
Conclusions : This study showed that herbal medicine can be effective for treating SSc. However, further studies are needed to develop novel medicine for SSc.
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KEYWORD
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Systemic sclerosis, Herbal medicine, Fibrosis
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